Europe

Rome: Italian Economy Minister Giancarlo Giorgetti cautioned against imposing retaliatory tariffs on the United States in response to President Donald Trump's decision to enforce sweeping tariffs on trade partners. Speaking at a business forum in Milan, Giorgetti emphasized the need to de-escalate tensions with the US, stating that they must avoid launching a policy of counter-tariffs that could harm everyone. He further suggested that to mitigate the potential negative economic impact of the tariffs, the European Union should allow member states to increase spending without breaching the bloc's fiscal rules. Under Trump's tariff plan, Italy, which holds a significant trade surplus with the US, will face a general tariff of 20 percent. Last Wednesday, President Trump announced comprehensive tariffs on US imports from various countries to bolster the manufacturing sector. The tariffs include a 34 percent on imports from China, 20 percent on imports from the European Union, and varying rates on other nations, with a minimum of 10 percent on all imports.

Americas

New York: The main stock indexes on the USWall Street Stock Exchange suffered heavy losses amounting to billions of dollars on Friday at the close of the trading week, impacted by the tariffs imposed by USPresident Donald Trump. The S&P 500 dropped by 322.44 points, equivalent to 5.97 percent, while the Nasdaq Composite Index lost 962.82 points or 5.82 percent of its value. The Dow Jones Industrial Average also fell by 2,231.07 points or 5.50 percent. President Donald Trump announced last Wednesday the imposition of "reciprocal" tariffs on all U.S. imports from around, with a minimum rate of 10 percent. The 10 percent tariffs on all U.S. imports are set to take effect Saturday, with higher tariffs scheduled to be imposed next Wednesday.

Asia

Tianjin: Chinese scientists have discovered the transport mechanism of lactate -- a critical metabolic fuel forcancercells -- and screened out silybin, a natural compound that disrupts this pathway to suppress livercancerproliferation. Cancercells can produce lactate under both hypoxic and normoxic conditions, which not only fuels tumor growth but also impairs immune surveillance by inhibiting immune cell function. After lactate production, the monocarboxylate transporter (MCT1) plays a pivotal role in lactate transport. MCT1 exports lactate fromcancercells to maintain intracellular pH balance while delivering energy to neighboring tumor cells. Read Also Madagascar's ancestral martial art Moraingy seeks recognition Video shows last moments for slain Gaza aid workers, Red Crescent says 'I don't have a voice in my head': Life with no inner monologue 'No one to return to': Afghans fear Pakistan deportation By deciphering the transport mechanism of MCT1 and disrupting lactate transport, a research team led by Ye Sheng, professor at Tianjin University, has unveiled a promising therapeutic strategy forcancerintervention. The study found that MCT1's efficient lactate transport hinges on precise amino acid interactions. Building on this discovery, the researchers identified silybin -- a natural compound derived from traditional Chinese medicine -- as an MCT1 blocker. Silybin binds precisely to the transporter's substrate pocket, disrupting MCT1 function and leading to toxic accumulation withincancercells. Laboratory experiments confirmed that silybin inhibits tumor growth in both cell cultures and animal models, highlighting its potential as a promising anti-canceragent, Ye said. "This research not only deepens our understanding ofcancermetabolism but also lays the groundwork for developing next-generationcancertherapies. We aim to deliver safer and more effective treatment options tocancerpatients in the near future," Ye added.